Guest essay by Eric Worrall
Don’t take aspirin without talking to your doctor – aspirin can have nasty and sometimes fatal side effects, even in small doses. However, a recent Israeli study of 10,477 patient records suggests a 29% reduction in Covid-19 infection and deaths among regular users of therapeutic aspirin.
According to Israeli research, aspirin could protect against COVID-19
According to researchers, people who take small doses are 29% less likely to be positive than others. Those who get COVID recover faster and with reduced after-effects
By NATHAN JEFFAY Today at 3:20 p.m.
Aspirin, one of the oldest and most widely used drugs, prevents COVID-19 infections, as Israeli scientists have claimed in “exciting” findings.
In the peer-reviewed study, they found that patients taking small doses of aspirin were 29 percent less likely to test positive in a sample of Israeli PCR tests. They compared 10,477 results to medical records showing which preventive drugs patients were taking.
“We were very excited to see a sharp decrease in the proportion of people who tested positive. This is promising indication that aspirin, such a well-known and inexpensive drug, can be helpful in combating the pandemic,” said Milana Frenkel-Morgenstern from Die Bar Ilan University told The Times of Israel.
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The aspirin study focused on people who are taking 75-milligram doses of the drug for the primary prevention of cardiovascular disease but have not yet had any such diseases. The results were adjusted to take into account age and comorbidities.
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“The fact that we have seen that it is not just the likelihood of infection but also the duration of the illness suggests the possibility that there are biological benefits to taking aspirin,” he said.
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Read more: https://www.timesofisrael.com/aspirin-may-protect-against-covid-19-israeli-research-finds/
The abstract of the study;
The use of aspirin for the primary prevention of cardiovascular disease is linked to a lower chance of COVID-19 infection
Eugene Merzon 1 2, Ilan Green 1 2, Shlomo Vinker 1 2, Avivit Golan-Cohen 1 2, Alessandro Gorohovski 3, Eva Avramovich 1 3, Milana Frenkel-Morgenstern 4, Eli Magen 1 5
PMID: 33621437
DOI: 10.1111 / febs.15784
abstract
Acetylsalicylic acid (aspirin) is commonly used for the primary and secondary prevention of cardiovascular diseases. Aspirin use has been linked to better results in COVID-19 positive patients. We hypothesized that using aspirin to prevent primary cardiovascular disease could have a protective effect on susceptibility to COVID-19 and disease duration. We conducted a retrospective population-based cross-sectional study using data from the Leumit Health Services database. The proportion of patients treated with aspirin was significantly lower in the COVID-19 positive group than in the COVID-19 negative group (73 (11.03%) versus 1548 (15.77%); p = 0.001). Aspirin use was associated with a lower likelihood of COVID-19 infection compared to non-users (adjusted OR 0.71 (95% CI, 0.52-0.99; p = 0.041). Aspirin users were older (68, 06 ± 12.79 versus 56.63 ± 12.28) years old; p <0.001) showed a lower BMI (28.77 ± 5.4 versus 30.37 ± 4.55; p <0.0189) and showed a higher prevalence of high blood pressure (56, 76.71%), diabetes (47, 64.38%) and COPD (11, 15.07%) than those who did not use aspirin (151, 25.64%, p < 0.001; 130, 22.07%, p <0.001; or 43, 7.3%, p = 0.023). In addition, COVID-19 disease duration (viewed as the time between the first positive and second negative COVID-19 RT-PCR test results) among aspirin users was significantly shorter compared to aspirin non-users (19.8 ± 7.8 versus 21.9 ± 7.9 p = 0.045). In hospitalized COVID positive patients, a higher proportion of surviving subjects were treated with aspirin (20, 19.05%) than 1 dead subject (14.29%), although this difference was not significant (p = 0.449). we observed an inverse relationship between the likelihood of COVID-19 infection, disease duration and mortality, and the use of aspirin for primary prevention.
Read more: https://pubmed.ncbi.nlm.nih.gov/33621437/
The study seems to focus on the obvious correlation, it does not seem to be concerned with the reason for the obvious therapeutic benefit.
One possible explanation is that aspirin is a Anti-inflammatorywhat could be the reason for its apparent effectiveness.
This is not the first time I’ve seen claims about the effectiveness of an anti-inflammatory agent against Covid. Another powerful one Anti-inflammatoryButesonide was recently claimed by Oxford University and Queensland University to reduce severe Covid symptoms by 90% and improve survival dramatically.
The highly malignant hydroxychloroquine, once a widespread anti-malarial drug, is used secondarily in the long term Anti-inflammatory Treatment of arthritis. My French friend told me that hydroxychloroquine was a non-prescription over-the-counter drug in France until President Macron banned it in early 2020 to prevent people from self-medication to treat their Covid symptoms.
I don’t know about you guys, but I think I’m starting to see a pattern. Certainly this clash of independent claims is that three are unrelatedly powerful Anti-inflammatory Medicines are therapeutically effective against Covid-19, it is worthwhile for someone in the medical community to take a closer look.
A note of caution – these are early days. It is possible that claims about the therapeutic benefits of Covid for some or all of the drugs I have listed are false.
However, it is also possible that claims about the therapeutic benefits of Covid are true for all three drugs I have mentioned. When the three are listed Anti-inflammatory Medications help reduce Covid symptoms because of them Anti-inflammatory Properties, these three anti-inflammatory agents could just be the tip of the iceberg – there could be a number of them anti-inflammatory agents that are useful for treating Covid. Maybe there is a cheap generic drug out there somewhere Anti-inflammatory That’s even more potent than butesonide’s claimed effectiveness of just sitting on a shelf somewhere and waiting for a doctor to notice.
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